Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics.
Identifieur interne : 001327 ( Main/Exploration ); précédent : 001326; suivant : 001328Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics.
Auteurs : Fekadu Yadetie [Norvège] ; Stephen Butcher ; Hilde E. F Rde ; Coen Campsteijn ; Jean-Marie Bouquet ; Odd A. Karlsen ; France Denoeud ; Raghu Metpally ; Eric M. Thompson ; J Robert Manak ; Anders Goks Yr ; Daniel ChourroutSource :
- BMC genomics [ 1471-2164 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Bases de données génétiques, Benzo[a]pyrène (pharmacologie), Clofibrate (pharmacologie), Cytochrome P-450 enzyme system (), Cytochrome P-450 enzyme system (génétique), Cytochrome P-450 enzyme system (métabolisme), Génome, Inactivation métabolique (génétique), Régulation de l'expression des gènes (), Réseaux de régulation génique, Urochordata (), Urochordata (génétique), Urochordata (métabolisme), Xénobiotique (pharmacologie).
- MESH :
- génétique : Cytochrome P-450 enzyme system, Inactivation métabolique, Urochordata.
- métabolisme : Cytochrome P-450 enzyme system, Urochordata.
- pharmacologie : Benzo[a]pyrène, Clofibrate, Xénobiotique.
- Animaux, Bases de données génétiques, Cytochrome P-450 enzyme system, Génome, Régulation de l'expression des gènes, Réseaux de régulation génique, Urochordata.
English descriptors
- KwdEn :
- Animals, Benzo(a)pyrene (pharmacology), Clofibrate (pharmacology), Cytochrome P-450 Enzyme System (classification), Cytochrome P-450 Enzyme System (genetics), Cytochrome P-450 Enzyme System (metabolism), Databases, Genetic, Gene Expression Regulation (drug effects), Gene Regulatory Networks, Genome, Inactivation, Metabolic (genetics), Urochordata (drug effects), Urochordata (genetics), Urochordata (metabolism), Xenobiotics (pharmacology).
- MESH :
- chemical , classification : Cytochrome P-450 Enzyme System.
- chemical , genetics : Cytochrome P-450 Enzyme System.
- chemical , metabolism : Cytochrome P-450 Enzyme System.
- chemical , pharmacology : Benzo(a)pyrene, Clofibrate, Xenobiotics.
- drug effects : Gene Expression Regulation, Urochordata.
- genetics : Inactivation, Metabolic, Urochordata.
- metabolism : Urochordata.
- Animals, Databases, Genetic, Gene Regulatory Networks, Genome.
Abstract
Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics have not been well investigated in most invertebrates. Here, we performed genome survey for key defensome genes in Oikopleura dioica genome, and explored genome-wide gene expression using high density tiling arrays with over 2 million probes, in response to two model xenobiotic chemicals - the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo).
DOI: 10.1186/1471-2164-13-55
PubMed: 22300585
Affiliations:
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Le document en format XML
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F Rde</name></author><author><name sortKey="Campsteijn, Coen" sort="Campsteijn, Coen" uniqKey="Campsteijn C" first="Coen" last="Campsteijn">Coen Campsteijn</name></author><author><name sortKey="Bouquet, Jean Marie" sort="Bouquet, Jean Marie" uniqKey="Bouquet J" first="Jean-Marie" last="Bouquet">Jean-Marie Bouquet</name></author><author><name sortKey="Karlsen, Odd A" sort="Karlsen, Odd A" uniqKey="Karlsen O" first="Odd A" last="Karlsen">Odd A. Karlsen</name></author><author><name sortKey="Denoeud, France" sort="Denoeud, France" uniqKey="Denoeud F" first="France" last="Denoeud">France Denoeud</name></author><author><name sortKey="Metpally, Raghu" sort="Metpally, Raghu" uniqKey="Metpally R" first="Raghu" last="Metpally">Raghu Metpally</name></author><author><name sortKey="Thompson, Eric M" sort="Thompson, Eric M" uniqKey="Thompson E" first="Eric M" last="Thompson">Eric M. Thompson</name></author><author><name sortKey="Manak, J Robert" sort="Manak, J Robert" uniqKey="Manak J" first="J Robert" last="Manak">J Robert Manak</name></author><author><name sortKey="Goks Yr, Anders" sort="Goks Yr, Anders" uniqKey="Goks Yr A" first="Anders" last="Goks Yr">Anders Goks Yr</name></author><author><name sortKey="Chourrout, Daniel" sort="Chourrout, Daniel" uniqKey="Chourrout D" first="Daniel" last="Chourrout">Daniel Chourrout</name></author></analytic><series><title level="j">BMC genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Benzo(a)pyrene (pharmacology)</term><term>Clofibrate (pharmacology)</term><term>Cytochrome P-450 Enzyme System (classification)</term><term>Cytochrome P-450 Enzyme System (genetics)</term><term>Cytochrome P-450 Enzyme System (metabolism)</term><term>Databases, Genetic</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Regulatory Networks</term><term>Genome</term><term>Inactivation, Metabolic (genetics)</term><term>Urochordata (drug effects)</term><term>Urochordata (genetics)</term><term>Urochordata (metabolism)</term><term>Xenobiotics (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bases de données génétiques</term><term>Benzo[a]pyrène (pharmacologie)</term><term>Clofibrate (pharmacologie)</term><term>Cytochrome P-450 enzyme system ()</term><term>Cytochrome P-450 enzyme system (génétique)</term><term>Cytochrome P-450 enzyme system (métabolisme)</term><term>Génome</term><term>Inactivation métabolique (génétique)</term><term>Régulation de l'expression des gènes ()</term><term>Réseaux de régulation génique</term><term>Urochordata ()</term><term>Urochordata (génétique)</term><term>Urochordata (métabolisme)</term><term>Xénobiotique (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzo(a)pyrene</term><term>Clofibrate</term><term>Xenobiotics</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Urochordata</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Inactivation, Metabolic</term><term>Urochordata</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytochrome P-450 enzyme system</term><term>Inactivation métabolique</term><term>Urochordata</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Urochordata</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochrome P-450 enzyme system</term><term>Urochordata</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Benzo[a]pyrène</term><term>Clofibrate</term><term>Xénobiotique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Databases, Genetic</term><term>Gene Regulatory Networks</term><term>Genome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bases de données génétiques</term><term>Cytochrome P-450 enzyme system</term><term>Génome</term><term>Régulation de l'expression des gènes</term><term>Réseaux de régulation génique</term><term>Urochordata</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics have not been well investigated in most invertebrates. Here, we performed genome survey for key defensome genes in Oikopleura dioica genome, and explored genome-wide gene expression using high density tiling arrays with over 2 million probes, in response to two model xenobiotic chemicals - the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo).</div></front></TEI><affiliations><list><country><li>Norvège</li></country></list><tree><noCountry><name sortKey="Bouquet, Jean Marie" sort="Bouquet, Jean Marie" uniqKey="Bouquet J" first="Jean-Marie" last="Bouquet">Jean-Marie Bouquet</name><name sortKey="Butcher, Stephen" sort="Butcher, Stephen" uniqKey="Butcher S" first="Stephen" last="Butcher">Stephen Butcher</name><name sortKey="Campsteijn, Coen" sort="Campsteijn, Coen" uniqKey="Campsteijn C" first="Coen" last="Campsteijn">Coen Campsteijn</name><name sortKey="Chourrout, Daniel" sort="Chourrout, Daniel" uniqKey="Chourrout D" first="Daniel" last="Chourrout">Daniel Chourrout</name><name sortKey="Denoeud, France" sort="Denoeud, France" uniqKey="Denoeud F" first="France" last="Denoeud">France Denoeud</name><name sortKey="F Rde, Hilde E" sort="F Rde, Hilde E" uniqKey="F Rde H" first="Hilde E" last="F Rde">Hilde E. F Rde</name><name sortKey="Goks Yr, Anders" sort="Goks Yr, Anders" uniqKey="Goks Yr A" first="Anders" last="Goks Yr">Anders Goks Yr</name><name sortKey="Karlsen, Odd A" sort="Karlsen, Odd A" uniqKey="Karlsen O" first="Odd A" last="Karlsen">Odd A. Karlsen</name><name sortKey="Manak, J Robert" sort="Manak, J Robert" uniqKey="Manak J" first="J Robert" last="Manak">J Robert Manak</name><name sortKey="Metpally, Raghu" sort="Metpally, Raghu" uniqKey="Metpally R" first="Raghu" last="Metpally">Raghu Metpally</name><name sortKey="Thompson, Eric M" sort="Thompson, Eric M" uniqKey="Thompson E" first="Eric M" last="Thompson">Eric M. Thompson</name></noCountry><country name="Norvège"><noRegion><name sortKey="Yadetie, Fekadu" sort="Yadetie, Fekadu" uniqKey="Yadetie F" first="Fekadu" last="Yadetie">Fekadu Yadetie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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